Idiopathic histaminergic angioedema without wheals: a case series of 31 patients

Autor: Charles Faisant, Alban Deroux, C. Mansard, Isabelle Boccon-Gibod, Pauline Pralong, C Dumestre Perard, C. Chatain, Laurence Bouillet
Přispěvatelé: Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Grenoble, Centre de référence des angioedèmes à kinines (CREAK), Service d'immunologie [CHU Grenoble], CHU de Grenoble, Barrière Naturelle et Infectiosité (TIMC-BNI ), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clinique de Dermatologie Allergologie et Photobiologie, Centre Hospitalier Universitaire [Grenoble] (CHU), Service de médecine interne [CHU Grenoble], National Angiodema Reference Centre, Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Barrière Naturelle et Infectiosité (TIMC-IMAG-BNI), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Département de dermatologie, allergologie et photobiologie [Hôpital Michallon du CHU Grenoble Alpes], Centre Hospitalier Universitaire [Grenoble] (CHU)-Hôpital Michallon
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Allergy
Delayed Diagnosis
Urticaria
Respiratory System
MESH: Angioedemas
Hereditary
Disease
030207 dermatology & venereal diseases
0302 clinical medicine
Epidemiology
Immunology and Allergy
MESH: Urticaria
Drug Dosage Calculations
Mast Cells
MESH: Respiratory System
Skin
MESH: Aged
MESH: Middle Aged
Middle Aged
3. Good health
medicine.anatomical_structure
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Female
medicine.symptom
MESH: Histamine
Histamine
Adult
medicine.medical_specialty
Immunology
Histamine Antagonists
03 medical and health sciences
Intensive care
medicine
Humans
MESH: Drug Dosage Calculations
Aged
Retrospective Studies
Inflammation
MESH: Humans
Angioedema
business.industry
Angioedemas
Hereditary
Histaminergic
MESH: Adult
MESH: Retrospective Studies
Original Articles
medicine.disease
Dermatology
MESH: Male
Surgery
MESH: Delayed Diagnosis
030228 respiratory system
Airway
business
MESH: Histamine Antagonists
MESH: Female
Respiratory tract
Zdroj: Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2016, 185 (1), pp.81-85. ⟨10.1111/cei.12789⟩
Clinical and Experimental Immunology, 2016, 185 (1), pp.81-85. ⟨10.1111/cei.12789⟩
ISSN: 0009-9104
1365-2249
DOI: 10.1111/cei.12789⟩
Popis: Summary Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-AAE patients. From 2014 to 2015, 534 patients were seen at our national reference centre for angioedema and/or urticaria. Among them, we identified 31 patients with idiopathic histaminergic acquired angioedema without wheals (IH-AAE). Thirty-one patients (15 men and 16 women) with a mean age of 50 years met the criteria for IH-AAE. The average delay in diagnosis was 6·3 years. A history of allergy was found in 12 patients (38·7%), nine suffering from allergic rhinitis. The mean duration of attacks was 28·1 h. The AE attack was located in the upper respiratory tract in 54·8% of cases (17 patients). A lingual location was found in 29% of patients. Men were more likely than women to have an upper airway involvement. No intubations or admissions to intensive care units were reported. The dosage of anti-histamines to control the symptoms was onefold the recommended dose in 51·6% of patients (16 patients), twofold in 32% (10 patients) and three–fourfold in 16·1% (five patients). IH-AAE is characterized by an important delay in diagnosis, a frequent involvement of the upper airway and a benign course during attacks. As in CU, a trial of up to fourfold dose of H1-anti-histamines may be necessary to control symptoms.
Databáze: OpenAIRE
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