Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors
| Autor: | Per Magne Ueland, Øivind Midttun, Merete Valen, Arve Ulvik, Clara Gram Gjesdal, Hilde Berner Hammer, Ellen M Apalset, Jon Sigurd Sande |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Vitamin Xanthurenates medicine.medical_specialty Nutritional Status Medicine (miscellaneous) Gastroenterology Etanercept Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Adalimumab Humans Longitudinal Studies Pyridoxal Kynurenine 030203 arthritis & rheumatology Nutrition and Dietetics Tumor Necrosis Factor-alpha business.industry Middle Aged medicine.disease Vitamin B 6 Infliximab Golimumab 030227 psychiatry C-Reactive Protein Treatment Outcome chemistry Pyridoxal Phosphate Rheumatoid arthritis Female Tumor Necrosis Factor Inhibitors Vitamin B 6 Deficiency business Biomarkers Rheumatism medicine.drug |
| Zdroj: | The Journal of Nutrition. 149:770-775 |
| ISSN: | 0022-3166 |
| Popis: | BACKGROUND A frequent observation in inflammatory conditions, including rheumatoid arthritis (RA), is low circulating amounts of pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B-6. Recently, a functional marker of vitamin B-6 status, the ratio of 3-hydroxykynurenine (HK): xanthurenic acid (XA) in plasma (HK: XA), was proposed. OBJECTIVE We investigated vitamin B-6 status in patients with RA before and after established treatment with TNFα inhibitors. METHODS We performed a longitudinal study of RA patients (n = 106, 36% men, median age 54 y) starting first treatment with a TNFα inhibitor (infliximab, etanercept, adalimumab, golimumab, or certolizumab). Clinical assessment (Disease Activity Score for 28 standard joints, DAS28), joint ultrasonography, and blood draw were performed at baseline and after 3 mo treatment. Plasma concentrations of PLP, HK, and XA were measured by liquid chromatography-tandem mass spectrometry. Associations of changes in vitamin B-6 markers with change in DAS28 were assessed by generalized additive models regression and with European League Against Rheumatism (EULAR) response categories by linear regression. RESULTS At baseline PLP was inversely correlated with CRP (ρ = -0.27, P = 0.007), whereas HK: XA correlated with DAS28 (ρ = 0.46, P |
| Databáze: | OpenAIRE |
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