Impact of different therapies on the survival of patients with stage I-IIA cervical cancer with intermediate risk factors
| Autor: | Anqi Yan, Qinjiao Wu, Jichan Nie, Zhiyong Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cervical cancer
Oncology medicine.medical_specialty Chemotherapy Univariate analysis business.industry medicine.medical_treatment General Medicine medicine.disease Radiation therapy 03 medical and health sciences 0302 clinical medicine Obstetrics and gynaecology 030220 oncology & carcinogenesis Internal medicine Cohort medicine Adjuvant therapy Original Article 030212 general & internal medicine Stage (cooking) business |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5839 |
| Popis: | BACKGROUND: The aim of this study was to determine the effects of different therapies on patients with cervical cancer (CC) with intermediate risk factors. METHODS: Clinicopathological data of 596 patients diagnosed with stage I–IIA CC at the Obstetrics and Gynecology Hospital of Fudan University between January 2013 and November 2015 were retrospectively reviewed. Of the patients, 500 patients received adjuvant therapy including chemotherapy (CT), radiotherapy (RT), and sequential chemotherapy and radiotherapy (CT + RT). Patients who displayed at least one intermediate risk factor number were screened. RESULTS: The median follow-up was 62 months. The 5-year progression-free survival (PFS) and overall survival (OS) of the entire cohort were 90.4% and 90.9%, respectively. Univariate analysis showed that tumor stage, tumor size, pathological type, lymphovascular space invasion, and numbers of medium risk factors were not risk factors for early-stage CC. Compared with the control group, patients who received CT, RT, or CT + RT showed improved PFS and OS (P |
| Databáze: | OpenAIRE |
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