Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application
| Autor: | Mario Altamirano-Lozano, Juan José Rodríguez-Mercado, Yazmín Vázquez-Martínez, Rodrigo Anibal Mateos-Nava, Lucila Álvarez-Barrera |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Tail Offspring medicine.medical_treatment Intraperitoneal injection chemistry.chemical_element Physiology Embryonic Development Ribs 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences Mice Fetus Osteogenesis Pregnancy Forelimb Medicine Animals Thallium Maternal-Fetal Exchange 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences business.industry Ossification Embryogenesis Skull Abnormalities Drug-Induced Hindlimb Low birth weight chemistry Gestation Female medicine.symptom business |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 90 |
| ISSN: | 1873-1708 |
| Popis: | Thallium (Tl) is a highly toxic metal for human beings; higher amounts found in diverse fluids of pregnant women are associated with low birth weight and preterm birth. However, experimental data concerning their effects on the embryonic development of mammalian organisms are limited. Hence, in the present work, TI(I) acetate of 0, 4.6, 9.2, or 18.5 mg/kg body weight were administered by intraperitoneal injection to groups of 10 pregnant CD-1 mice on the 7th gestational day, and animals were sacrificed on day 18 of gestation. The fetuses obtained showed some variations, such as trunk bent over (18.5 mg/kg), tail variations (all doses), forelimbs malrotation and hind limbs (all doses). Skeletal examination of the fetuses showed a delay in the ossification of skull bones, ribs, and limbs (all doses). In conclusion, the Intraperitoneal injection of Tl(I) acetate to pregnant mice induced morphological variations and a delay of the fetus ossification. |
| Databáze: | OpenAIRE |
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