Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones
| Autor: | Xu Tian, Zhongnan Xu, Xiyong Yu, Zhixing Huang, Lutz Ackermann, Guangquan Mo, Zhixiong Ruan |
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| Rok vydání: | 2019 |
| Předmět: |
Electrolysis
010405 organic chemistry Chemistry Trifluoromethylation Organic Chemistry 010402 general chemistry Electrochemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences law.invention Catalysis chemistry.chemical_compound law Functional group Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 21:1237-1240 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | The catalyst-free electrochemical di- and trifluoromethylation/cyclization of N-substituted acrylamides was realized under external oxidant-free conditions. The strategy provides expedient access to fluoroalkylated oxindoles and 3,4-dihydroquinolin-2(1 H)-ones with ample scope and broad functional group tolerance by mild, direct electrolysis of sodium sulfinates in an undivided cell. Detailed mechanistic studies provided strong support for a SET-based reaction manifold. |
| Databáze: | OpenAIRE |
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