Stability of ribosomal protein mRNA and translational feedback regulation in Escherichia coli
| Autor: | Phillip Singer, Masayasu Nomura |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Ribosomal Proteins
Messenger RNA Repressor RNA Translation (biology) Biology medicine.disease_cause Molecular biology Feedback Cell biology Kinetics Ribosomal protein Protein Biosynthesis Translational regulation Escherichia coli Genetics Protein biosynthesis medicine RNA Messenger Molecular Biology |
| Zdroj: | Molecular and General Genetics MGG. 199:543-546 |
| ISSN: | 1432-1874 0026-8925 |
| DOI: | 10.1007/bf00330773 |
| Popis: | It was previously observed that the stability of ribosomal protein (r-protein) mRNA in Escherichia coli decreases under the conditions where its translation is feedback inhibited by repressor r-protein. We have now demonstrated that the stability of mRNA for r-proteins S13, S11 and S4 increases in a strain carrying a mutation in the gene for S4, a translational repressor regulating these r-proteins. The results confirm the previous observations that translational repression increases the decay rate of r-protein mRNA, and in addition, show that the half-life of S13-S4 r-protein mRNA in cells growing under ordinary conditions is significantly shorter than its inherent stability would predict, due to the operation of translational feedback regulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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