Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis
| Autor: | Pedro Robles, Anisa Turner, Beth Hill, Michael Winton, Andre Pires-daSilva, Christine Bateson, Giusy Zuco, Vikas Kache, Panagiota Paganopolou, Sally Adams |
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| Rok vydání: | 2020 |
| Předmět: |
AMPK
QH301-705.5 Physiology Offspring nematode Inheritance Patterns Plant Science mTORC1 Biology General Biochemistry Genetics and Molecular Biology Germline Epigenesis Genetic QH301 03 medical and health sciences 0302 clinical medicine Structural Biology Auanema Animals Epigenetics Biology (General) Caenorhabditis elegans Ecology Evolution Behavior and Systematics 030304 developmental biology Genetics 0303 health sciences Phenotypic plasticity Dauer Cell Biology Sex Determination Processes Sex determination Phenotype Chromatin Intergenerational inheritance Insulin receptor Germ Cells Histone acetylation biology.protein C. elegans General Agricultural and Biological Sciences 030217 neurology & neurosurgery Developmental Biology Biotechnology Research Article Transgenerational inheritance |
| Zdroj: | BMC Biology BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021) |
| ISSN: | 1741-7007 |
| Popis: | Background Environmental stimuli experienced by the parental generation influence the phenotype of subsequent generations (Demoinet et al., Proc Natl Acad Sci U S A 114:E2689-E2698, 2017; Burton et al., Nat Cell Biol 19:252–257, 2017; Agrawal et al., Nature 401:60-63, 1999). The effects of these stimuli on the parental generation may be passed through the germline, but the mechanisms at the basis of this non-Mendelian type of inheritance, their level of conservation, how they lead to adaptive vs non-adaptive, and intergenerational vs transgenerational inheritance are poorly understood. Here we show that modulation of nutrient-sensing pathways in the parental generation of the nematode Auanema freiburgensis regulates phenotypic plasticity of its offspring. Results In response to con-specific pheromones indicative of stress, AMP-activated protein kinase (AMPK), mechanistic target of rapamycin complex 1 (mTORC1), and insulin signaling regulate stress resistance and sex determination across one generation, and these effects can be mimicked by pathway modulators. The effectors of these pathways are closely associated with the chromatin, and their regulation affects the chromatin acetylation status in the germline. Conclusion These results suggest that highly conserved metabolic sensors regulate phenotypic plasticity through regulation of subcellular localization of their effectors, leading to changes in chromatin acetylation and epigenetic status of the germline. |
| Databáze: | OpenAIRE |
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