Expression and characterization of a dopamine D4R variant associated with delusional disorder
| Autor: | Marco Catalano, Maria Nobile, Enrico Smeraldi, Marie Thérèse Zenner, Robert Henningsen, Olivier Civelli, Deborah S. Hartman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Quinpirole
Epinephrine medicine.medical_treatment Dopamine Biophysics Antidepressant CHO Cells Biology Pharmacology Transfection Biochemistry Antipsychotic Exon Norepinephrine Structural Biology Cricetinae Genetics medicine Animals Humans DFR1 Polymorphism Receptor Molecular Biology Clozapine Polymorphism Genetic Schizophrenia Paranoid Delusional disorder Receptors Dopamine D2 Receptors Dopamine D4 Genetic Variation Cell Biology medicine.disease Recombinant Proteins Kinetics Guanosine 5'-O-(3-Thiotriphosphate) Dopamine Agonists Schizophrenia Dopamine Antagonists medicine.drug Antipsychotic Agents |
| Zdroj: | FEBS letters. 422(2) |
| ISSN: | 0014-5793 |
| Popis: | Multiple genetic polymorphisms of the human dopamine D4 receptor (hD4R) have been identified including a 12 bp repeat in exon 1 associated with a psychotic condition called delusional disorder. Competition binding assays revealed minor pharmacological differences between the recombinant A1 (normal) and A2 (delusional) proteins with respect to quinpirole and the antipsychotic clozapine, however no functional differences were detected for receptor activation by dopamine, epinephrine, or norepinephrine. Our results suggest that this polymorphism may only confer susceptibility to delusional disorder in combination with other genetic or environmental factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text