Snake Venom Components: Tools and Cures to Target Cardiovascular Diseases

Autor: Mohamad Rima, Christian Legros, Jean-Marc Sabatier, Jacinthe Frangieh, César Mattei, Ziad Fajloun, Daniel Henrion
Přispěvatelé: Lebanese University [Beirut] (LU), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Leloup, Ludovic, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC)
Rok vydání: 2021
Předmět:
0301 basic medicine
Platelet aggregation
Bioactive molecules
Pharmaceutical Science
Review
Pharmacology
Cardiovascular System
Analytical Chemistry
0302 clinical medicine
Drug Discovery
Medicine
MESH: Animals
snake venom
anti-platelet agent
3. Good health
Chemistry (miscellaneous)
Snake venom
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Fibrinolytic enzyme
Molecular Medicine
MESH: Cardiovascular Agents
Snake Venoms
vasorelaxant effect
Models
Biological
complex mixtures
drugs discovery
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
hypotensive agent
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Physical and Theoretical Chemistry
MESH: Snake Venoms
MESH: Humans
MESH: Cardiovascular System
business.industry
Organic Chemistry
MESH: Models
Biological
MESH: Cardiovascular Diseases
Cardiovascular Agents
cardiovascular diseases
030104 developmental biology
Secretory protein
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Molecular targets
business
030217 neurology & neurosurgery
Zdroj: Molecules
Molecules, 2021, 26 (8), pp.2223. ⟨10.3390/molecules26082223⟩
Molecules, Vol 26, Iss 2223, p 2223 (2021)
Molecules, MDPI, 2021, 26 (8), pp.2223. ⟨10.3390/molecules26082223⟩
ISSN: 1420-3049
Popis: International audience; Cardiovascular diseases (CVDs) are considered as a major cause of death worldwide. Therefore, identifying and developing therapeutic strategies to treat and reduce the prevalence of CVDs is a major medical challenge. Several drugs used for the treatment of CVDs, such as captopril, emerged from natural products, namely snake venoms. These venoms are complex mixtures of bioactive molecules, which, among other physiological networks, target the cardiovascular system, leading to them being considered in the development and design of new drugs. In this review, we describe some snake venom molecules targeting the cardiovascular system such as phospholipase A2 (PLA2), natriuretic peptides (NPs), bradykinin-potentiating peptides (BPPs), cysteine-rich secretory proteins (CRISPs), disintegrins, fibrinolytic enzymes, and three-finger toxins (3FTXs). In addition, their molecular targets, and mechanisms of action—vasorelaxation, inhibition of platelet aggregation, cardioprotective activities—are discussed. The dissection of their biological effects at the molecular scale give insights for the development of future snake venom-derived drugs.
Databáze: OpenAIRE
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