Randomized comparison of G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells: effects on hematopoietic recovery after high-dose chemotherapy
| Autor: | Douglas Adkins, Paul J. Petruska, R Niemeyer, Frank R. Dunphy, William S. Velasquez, W McIntyre, N Kronmueller, Gary Spitzer, M Mathews, Bowers C |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning medicine.medical_treatment Urology CD34 Antineoplastic Agents Buffy coat Transplantation Autologous Neoplasms Granulocyte Colony-Stimulating Factor medicine Humans Platelet Aged Bone Marrow Transplantation Transplantation Chemotherapy business.industry Granulocyte-Macrophage Colony-Stimulating Factor Hematology Middle Aged Survival Analysis Hematopoietic Stem Cell Mobilization Blood Cell Count Granulocyte colony-stimulating factor Surgery Haematopoiesis medicine.anatomical_structure Blood Component Removal Female Bone marrow Stem cell business |
| Zdroj: | Bone Marrow Transplantation. 20:921-930 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | Fifty patients with either lymphoid or selected solid tumor malignancies were apheresed an identical number of times for PBSC collection after being randomized to receive either G-CSF 10 microg/kg/day alone (arm I), or G-CSF at the same dose with GM-CSF 5 microg/kg/day (arm II). Growth factor(s) was/were given as the stem cell mobilizing agent for 5 days before the start of PBSC collection, and were continued throughout the 4 days of apheresis. Aspiration and cryopreservation of autologous bone marrow occurred on day 3 or 4 of growth factor(s). Thirty-one of 50 patients received one cycle only at time of evaluation, and 19 patients received two cycles of HDCT, each supported with PBSC with or without autologous bone marrow. No patients received growth factors post-autologous stem cell transplant, unless the absolute neutrophils count (ANC) failed to recover toor = 100/microl by day +18 post-transplant. The median number of days to recovery of ANC to 100/microl, 500/microl and 1000/microl, and of platelet counts to 20000/microl, 50000/microl and 100000/microl after either cycle 1 or cycle 2 of HDCT and the number of febrile days and platelet and PRBC transfusion requirements was not significantly different between the two arms of the study. The duration of hospitalization was similar between study arms for cycle 1 of HDCT, but was 3.5 days less with arm II compared to arm I (P = 0.0248) for cycle 2 of HDCT. The bone marrow buffy coat and PBSC product mononuclear cell count (x 10(8)/kg) and CD34+ cell count (x 10(6)/kg) collected by each method of stem cell mobilization was not significantly different. There is questionable clinical benefit with PBSC products mobilized with the combination of G-CSF and GM-CSF vs G-CSF alone. Perhaps different dosages, schedules, or other growth factor combinations with G-CSF might enhance these differences. |
| Databáze: | OpenAIRE |
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