Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay
| Autor: | Eitan Lavi, Bronwyn A. Lucas, Lynne E. Maquat, Mikiko C. Siomi, Liran Carmel, Manuel Ares, Hana Cho, Lily Shiue, Keita Miyoshi, Sol Katzman |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Untranslated region Transposable element Evolution 1.1 Normal biological development and functioning RNA Stability Messenger Gene regulatory network RNA-binding protein Protein Serine-Threonine Kinases Biology behavioral disciplines and activities Evolution Molecular Mice 03 medical and health sciences Underpinning research Genetics Animals Humans Short Interspersed Nucleotide Elements RNA Messenger Sine Staufen-mediated mRNA decay convergent evolution 3' Untranslated Regions Multidisciplinary Three prime untranslated region Molecular Pyruvate Dehydrogenase Acetyl-Transferring Kinase RNA-Binding Proteins Biological Sciences Staufen1 AT Rich Sequence 030104 developmental biology Evolutionary biology UPF1 RNA psychological phenomena and processes Orthologous Gene SINEs |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 5 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1715531115 |
| Popis: | Primate-specific Alu short interspersed elements (SINEs) as well as rodent-specific B and ID (B/ID) SINEs can promote Staufen-mediated decay (SMD) when present in mRNA 3′-untranslated regions (3′-UTRs). The transposable nature of SINEs, their presence in long noncoding RNAs, their interactions with Staufen, and their rapid divergence in different evolutionary lineages suggest they could have generated substantial modification of posttranscriptional gene-control networks during mammalian evolution. Some of the variation in SMD regulation produced by SINE insertion might have had a similar regulatory effect in separate mammalian lineages, leading to parallel evolution of the Staufen network by independent expansion of lineage-specific SINEs. To explore this possibility, we searched for orthologous gene pairs, each carrying a species-specific 3′-UTR SINE and each regulated by SMD, by measuring changes in mRNA abundance after individual depletion of two SMD factors, Staufen1 (STAU1) and UPF1, in both human and mouse myoblasts. We identified and confirmed orthologous gene pairs with 3′-UTR SINEs that independently function in SMD control of myoblast metabolism. Expanding to other species, we demonstrated that SINE-directed SMD likely emerged in both primate and rodent lineages >20–25 million years ago. Our work reveals a mechanism for the convergent evolution of posttranscriptional gene regulatory networks in mammals by species-specific SINE transposition and SMD. |
| Databáze: | OpenAIRE |
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