Influence of recipient and donor IL-1 , IL-4, and TNF genotypes on the incidence of acute renal allograft rejection
| Autor: | C G Newstead, B Clark, H Lee, H C Gooi, J Stoves |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Graft Rejection
Genotype medicine.medical_treatment Histocompatibility Testing Human leukocyte antigen Pathology and Forensic Medicine Short Reports medicine Humans Kidney transplantation Kidney Polymorphism Genetic business.industry Interleukin General Medicine medicine.disease Kidney Transplantation Transplantation Cytokine medicine.anatomical_structure IL1A Acute Disease Immunology Cytokines Interleukin-4 business Polymorphism Restriction Fragment Length Interleukin-1 |
| Zdroj: | Journal of Clinical Pathology. 57:101-103 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.57.1.101 |
| Popis: | Aims: To determine whether polymorphisms of the genes encoding donor or recipient interleukin 1α (IL-1α), tumour necrosis factor α (TNFα), or IL-4 have any impact on the incidence of acute rejection after renal transplantation. Methods: All donors and recipients were genotyped for three polymorphisms in the three cytokine genes: IL1A −889, TNFA −308, and IL4 –590. Results: Statistical analysis of the data obtained revealed no association between the cytokine gene polymorphisms tested and the incidence of post-transplant acute rejection. After stratification for human leucocyte antigen (HLA) matching, it was found that kidneys from donors positive for the TNFA-A allele had a significantly increased incidence of acute rejection in HLA-DR mismatched transplants. Conclusions: This finding argues for prospective TNFA genotyping of renal donors, with avoidance of allocation of kidneys from donors positive for the TNFA-A allele to HLA-DR mismatched recipients. |
| Databáze: | OpenAIRE |
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