Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis
| Autor: | Tina Kold Jensen, Charles J. Weschler, Torben Sigsgaard, Sarka Langer, Michael Callesen, Gabriel Bekö, Arne Høst, Jørn Toftum, Geo Clausen |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Allergy Denmark Phthalic Acids Written questionnaire Eczema Clinical examination Immunoglobulin E Biochemistry Dermatitis Atopic Allergic sensitization chemistry.chemical_compound medicine Ingestion Humans Sensitization General Environmental Science Asthma biology business.industry Allergic diseases Phthalate Indoor environment Dust Atopic dermatitis medicine.disease Conjunctivitis Rhinitis Allergic medicine.anatomical_structure chemistry Child Preschool Immunology biology.protein Environmental Pollutants Female business |
| Zdroj: | Bekö, G, Callesen, M, Weschler, C J, Toftum, J, Langer, S, Sigsgaard, T, Høst, A, Kold Jensen, T & Clausen, G 2015, ' Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis ', Environmental Research, vol. 137C, pp. 432-439 . https://doi.org/10.1016/j.envres.2015.01.012 Bekö, G, Callesen, M, Weschler, C J, Toftum, J, Langer, S, Sigsgaard, T, Høst, A, Kold Jensen, T & Clausen, G 2015, ' Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis ', Environmental Research, vol. 137, no. February, pp. 432-439 . https://doi.org/10.1016/j.envres.2015.01.012 |
| DOI: | 10.1016/j.envres.2015.01.012 |
| Popis: | Studies in rodents indicate that phthalates can function as adjuvants, increasing the potency of allergens. Meanwhile, epidemiological studies have produced inconsistent findings regarding relationships between phthalate exposures and allergic disease in humans. The present study examined phthalate exposure and allergic sensitization in a large group of 3-5 year old children: 300 random controls and 200 cases with asthma, rhinoconjunctivitis or atopic dermatitis as reported in questionnaires. The children were clinically examined to confirm their health status. Blood samples were analyzed for IgE sensitization to 20 allergens. Adjusted logistic regressions were used to look for associations between phthalate exposure indicators (mass fractions in dust from children's homes and daycares, metabolites in urine, and estimated daily indoor intakes from dust ingestion, inhalation and dermal absorption) and sensitization and allergic disease. No direct associations were found between phthalate exposures and asthma, rhinoconjunctivitis or atopic dermatitis. However, among children with these diseases, there were significant associations between non-dietary exposures to DnBP, BBzP and DEHP in the indoor environment (mass fractions in dust or daily indoor intakes from dust ingestion, inhalation and dermal absorption) and allergic sensitization. Some exposure pathways were more strongly associated with sensitization than others, although the results are not conclusive and require confirmation. A number of the associations depended on accounting for a child's exposure in more than one environment (i.e., daycare facility as well as home). Significant associations were not observed between phthalate metabolites in urine, which reflected exposure from diet as well as indoor pathways, and allergic sensitization. |
| Databáze: | OpenAIRE |
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