Dosimetric impact of inter-observer catheter reconstruction variability in ultrasound-based high-dose-rate prostate brachytherapy
| Autor: | Ananth Ravi, Jure Murgic, Andrew Loblaw, Alexandru Nicolae, Laura D'Alimonte, Ivan Kruljac, Lior Dubnitzky, Gerard Morton, Niki Law, Lin Lu, Hans T. Chung, Aaron Cumal |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Observer (quantum physics) medicine.medical_treatment Brachytherapy Radiation Dosage Endosonography 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Urethra Prostate medicine Humans Dosimetry Radiology Nuclear Medicine and imaging Observer Variation business.industry Radiotherapy Planning Computer-Assisted Ultrasound Prostatic Neoplasms Radiotherapy Dosage medicine.disease Catheter medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Radiology business Prostate brachytherapy |
| Zdroj: | Brachytherapy. 17:306-312 |
| ISSN: | 1538-4721 |
| DOI: | 10.1016/j.brachy.2017.10.015 |
| Popis: | Purpose To investigate the dosimetric impact of interobserver catheter reconstruction variability in transrectal ultrasound–guided prostate high-dose-rate (HDR) brachytherapy. Methods and Materials Twenty consecutive patients with intermediate- or high-risk prostate cancer were treated with a single, 15-Gy HDR brachytherapy boost as part of this study. The treated plan was used as the study reference plan (PR). Three expert treatment planners (observers) manually reconstructed the catheter paths on the static three-dimensional transrectal ultrasound images, and new plans were generated from the updated positions (POBS); subsequently, the dwell time and positions from the POBS plans were superimposed on the PR catheter paths to evaluate the dosimetric effect of the interobserver variations (PEVAL). Plans from each group were stratified by observer and by number of catheters (12 or 16) and then compared using a one-way Kruskal–Wallis H test with post hoc Mann–Whitney U tests reserved for significant variations (α = 0.05). Results Greater than 98.9% of catheter reconstruction variations were Conclusions Limiting interobserver variability, and its effects on prostate HDR brachytherapy plan quality, is critical to achieving good dosimetric outcomes; small variations in catheter reconstruction may translate to inadequate PTV coverage, excessive urethral dose, or both. |
| Databáze: | OpenAIRE |
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