A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion
| Autor: | Baogang Qian, Robert F. Rudy, Scott T. Weiss, Nareerat Charoenvimolphan, Robert M. Friedlander, Rose Du, Annerose Berndt |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Candidate gene Pathology medicine.medical_specialty Biopsy lcsh:Medicine Infarction Genome-wide association study Biology Polymorphism Single Nucleotide Article Brain Ischemia Mice 03 medical and health sciences 0302 clinical medicine Inbred strain medicine.artery medicine Animals cardiovascular diseases Allele lcsh:Science Alleles Genetic Association Studies Multidisciplinary medicine.diagnostic_test Penumbra lcsh:R Infarction Middle Cerebral Artery medicine.disease Stroke Disease Models Animal 030104 developmental biology Middle cerebral artery lcsh:Q Disease Susceptibility Biomarkers 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-41592-5 |
| Popis: | Following ischemic stroke, the penumbra, at-risk neural tissue surrounding the core infarct, survives for a variable period of time before progressing to infarction. We investigated genetic determinants of the size of penumbra in mice subjected to middle cerebral artery occlusion (MCAO) using a genome-wide approach. 449 male mice from 33 inbred strains underwent MCAO for 6 hours (215 mice) or 24 hours (234 mice). A genome-wide association study using genetic data from the Mouse HapMap project was performed to examine the effects of genetic variants on the penumbra ratio, defined as the ratio of the infarct volume after 6 hours to the infarct volume after 24 hours of MCAO. Efficient mixed model analysis was used to account for strain interrelatedness. Penumbra ratio differed significantly by strain (F = 2.7, P Clint1, Nbea, Smtnl2, Rin3, Dclk1, and Slc24a4. |
| Databáze: | OpenAIRE |
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