Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer
| Autor: | Zhuangjian Ye, Min Liu, Laisheng Li, Chumei Huang, Jianbo Liang, Xiangdong Xu, Jianxin Wan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Frizzled Poor prognosis Article Subject Clinical Biochemistry Youden's J statistic Breast Neoplasms Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor Genetics medicine Humans Stage (cooking) Molecular Biology Lymph node lcsh:R5-920 business.industry Biochemistry (medical) Area under the curve Membrane Proteins General Medicine Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Female lcsh:Medicine (General) business Research Article |
| Zdroj: | Disease Markers Disease Markers, Vol 2019 (2019) |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Purpose. Secreted frizzled-related protein 2 (sFRP2) is a secreted protein associated with cancer drug resistance and metastasis. However, few studies have reported serum sFRP2 levels in breast cancer. We evaluated serum sFRP2 as a potential biomarker for breast cancer. Methods. Serum sFRP2 concentrations were detected in 274 breast cancer patients along with 147 normal healthy controls by enzyme-linked immunosorbent assay (ELISA). Diagnostic significance was evaluated by area under the curve (AUC) analysis and the Youden index. Prognostic significance was determined by Kaplan-Meier survival method and univariate and multivariate Cox proportional hazard regression model analyses. Results. Serum sFRP2 was elevated in breast cancer patients compared to normal healthy controls (P<0.001). The sensitivity of sFRP2 in diagnosing breast cancer was 76.9% at a specificity of 76.6%. Elevated serum sFRP2 levels are associated with primary tumor size, TNM stage, and lymph node metastases. The Kaplan-Meier curves showed a significant association of serum sFRP2 with progression-free survival. The multivariate Cox analysis confirmed that high serum sFRP2 was an independent prognostic factor for poor prognosis (HR=3.89, 95% CI=1.95-7.68, P=0.001). Conclusions. In conclusion, serum sFRP2 may serve as a potential biomarker for breast cancer diagnosis and prognostic evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text