The response of glandular gastric transcriptome to T-2 toxin in chicks
| Autor: | Jie-Fan Dai, Lv-Hui Sun, Desheng Qi, You-Wei Wang, Jing-Jing Luo, Yu Zhang, Ni-Ya Zhang, Jin-Tao Wei, Mahmoud Mohamed Khalil, Hua Sun |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Administration Oral Inflammation Biology Toxicology medicine.disease_cause Desquamation Transcriptome Internal medicine medicine Animals Edema RNA Messenger Wound Healing Toxin General Medicine T-2 Toxin Endocrinology Gastric Mucosa Apoptosis medicine.symptom Carcinogenesis Wound healing Chickens Food Science |
| Zdroj: | Food and Chemical Toxicology. 132:110658 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2019.110658 |
| Popis: | This study was conducted to determine the effect of T-2 toxin on the transcriptome of the glandular stomach in chicks using RNA-sequencing (RNA-Seq). Four groups of 1-day-old Cobb male broilers (n = 4 cages/group, 6 chicks/cage) were fed a corn-soybean-based diet (control) and control supplemented with T-2 toxin at 1.0, 3.0, and 6.0 mg/kg, respectively, for 2 weeks. The histological results showed that dietary supplementation of T-2 toxin at 3.0 and 6.0 mg/kg induced glandular gastric injury including serious inflammation, increased inflammatory cells, mucosal edema, and necrosis and desquamation of the epithelial cells in the glandular stomach of chicks. RNA-Seq analysis revealed that there were 671, 1393, and 1394 genes displayed ≥2 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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