Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting
| Autor: | Kornélia Tekes, Ágnes Inczefi-Gonda, Laszlo Tothfalusi, M. Hantos, György Csaba, Cs Karabélyos, Barbara Knippel |
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| Rok vydání: | 2004 |
| Předmět: |
Serotonin
medicine.medical_specialty Estrogen receptor Imprinting Psychological Mianserin Weaning Pharmacology Dexamethasone General Biochemistry Genetics and Molecular Biology Sexual Behavior Animal Glucocorticoid receptor Internal medicine medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics 5-HT receptor Brain Chemistry Hormonal imprinting business.industry General Medicine Rats Endocrinology Opioid Peptides Receptors Estrogen Hypothalamus Antidepressant Female Serotonin Antagonists business medicine.drug |
| Zdroj: | Life Sciences. 75:939-946 |
| ISSN: | 0024-3205 |
| Popis: | Four weeks old (weanling) female rats were treated with the tricyclic antidepressant and histamine/serotonin receptor blocker mianserin for studying its faulty hormonal imprinting effect. Measurements were done four months later. Brain serotonin levels significantly decreased in four regions (hippocampus, hypothalamus, striatum and brainstem), without any change in the cortex. Sexual activity of the treated and control rats was similar. Cerebrospinal fluid nocistatin level was one magnitude higher in the treated rats, than in the controls. The density of uterine estrogen receptors was significantly reduced, while binding capacity of glucocorticoid receptors of liver and thymus remained at control level. The results call attention to the possibility of 1. a broad spectrum imprinting at the time of weaning by a receptor level acting non-hormone molecule 2. imprinting of the brain in a non-neonatal period of life and 3. a very durable (lifelong?) effect of the late imprinting with an antidepressant. |
| Databáze: | OpenAIRE |
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