Small-Quantity Lipid-Based Nutrient Supplements Increase Infants' Plasma Essential Fatty Acid Levels in Ghana and Malawi : A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Trials
| Autor: | Yue-Mei Fan, Emma Kortekangas, Kathryn G. Dewey, Anna Lartey, Kristina Harris Jackson, Ulla Ashorn, Harriet Okronipa, Per Ashorn, Andrew Matchado, Brietta M Oaks, Charles D Arnold, Seth Adu-Afarwuah, Kenneth Maleta |
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| Přispěvatelé: | Tampere University, Clinical Medicine, Department of Paediatrics, BioMediTech |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Malawi
Linoleic acid Medicine (miscellaneous) Physiology Mismatch negativity 3121 Internal medicine Ghana law.invention chemistry.chemical_compound symbols.namesake Randomized controlled trial Essential fatty acid law Pregnancy parasitic diseases Medicine Humans Poisson regression Micronutrients Randomized Controlled Trials as Topic chemistry.chemical_classification Nutrition and Dietetics Fatty Acids Essential business.industry Fatty acid Infant Maternal Nutritional Physiological Phenomena Nutrients Micronutrient Lipids 3142 Public health care science environmental and occupational health chemistry Dietary Supplements symbols Female Analysis of variance 3111 Biomedicine business |
| Popis: | INTRODUCTION: Small-quantity (SQ) lipid-based nutrient supplements (LNSs) may influence infants' plasma fatty acid (FA) profiles, which could be associated with short- and long-term outcomes. OBJECTIVES: We aimed to determine the impact of SQ-LNS consumption on infants' plasma FA profiles in Ghana and Malawi. METHODS: Ghanaian (n = 1320) and Malawian (n = 1391) women ≤20 weeks pregnant were assigned to consume 60 mg iron and 400 μg folic acid daily until delivery [iron and folic acid (IFA) group], multiple-micronutrient supplements (MMNs) until 6 months postpartum (MMN group), or SQ-LNSs (∼7.8 linoleic acid:α-linolenic acid ratio) until 6 months postpartum (LNS group). LNS group infants received SQ-LNS from 6 to 18 months of age. We compared infant plasma FAs by intervention group in subsamples (n = 379 in Ghana; n = 442 in Malawi) at 6 and 18 months using ANOVA and Poisson regression models. Main outcomes were mean percentage compositions (%Cs; percentage of FAs by weight) of α-linolenic acid (ALA), linoleic acid (LA), EPA, DHA, and arachidonic acid (AA). RESULTS: At 6 months, LNS infants had greater mean ± SD ALA %Cs in Ghana (0.23 ± 0.08; IFA, 0.21 ± 0.06; MMN, 0.21 ± 0.07; P = 0.034) and Malawi (0.42 ± 0.16; IFA, 0.38 ± 0.15; MMN, 0.38 ± 0.14; P = 0.034) and greater AA values in Ghana (6.25 ± 1.24; IFA, 6.12 ± 1.13; MMN, 5.89 ± 1.24; P = 0.049). At 18 months, LNS infants had a tendency towards greater ALA (0.32 ± 0.16; IFA, 0.24 ± 0.08; MMN, 0.24 ± 0.10; P = 0.06) and LA (27.8 ± 3.6; IFA, 26.9 ± 2.9; MMN, 27.0 ± 3.1; P = 0.06) in Ghana, and greater ALA (0.45 ± 0.18; IFA, 0.39 ± 0.18; MMN, 0.39 ± 0.18; P |
| Databáze: | OpenAIRE |
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