Fast T1 and T2 mapping methods: the zoomed U-FLARE sequence compared with EPI and snapshot-FLASH for abdominal imaging at 11.7 Tesla
| Autor: | Sandra Plaza-García, Géraldine Pastor, María Jiménez-González, Marta Beraza, Torsten Reese |
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| Rok vydání: | 2016 |
| Předmět: |
Male
T2 mapping Biophysics Mice Nude Inversion recovery Kidney medulla Kidney Sensitivity and Specificity 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences Mice 0302 clinical medicine Nuclear magnetic resonance law Cell Line Tumor Abdomen Image Interpretation Computer-Assisted medicine Animals Humans Radiology Nuclear Medicine and imaging Physics Radiological and Ultrasound Technology medicine.diagnostic_test Echo-Planar Imaging Reproducibility of Results Magnetic resonance imaging Signal Processing Computer-Assisted Neoplasms Experimental Image Enhancement Diffusion Magnetic Resonance Imaging Mouse Kidney Snapshot (computer storage) High field 030217 neurology & neurosurgery Flare |
| Zdroj: | Magma (New York, N.Y.). 30(3) |
| ISSN: | 1352-8661 |
| Popis: | A newly adapted zoomed ultrafast low-angle RARE (U-FLARE) sequence is described for abdominal imaging applications at 11.7 Tesla and compared with the standard echo-plannar imaging (EPI) and snapshot fast low angle shot (FLASH) methods. Ultrafast EPI and snapshot-FLASH protocols were evaluated to determine relaxation times in phantoms and in the mouse kidney in vivo. Owing to their apparent shortcomings, imaging artefacts, signal-to-noise ratio (SNR), and variability in the determination of relaxation times, these methods are compared with the newly implemented zoomed U-FLARE sequence. Snapshot-FLASH has a lower SNR when compared with the zoomed U-FLARE sequence and EPI. The variability in the measurement of relaxation times is higher in the Look–Locker sequences than in inversion recovery experiments. Respectively, the average T1 and T2 values at 11.7 Tesla are as follows: kidney cortex, 1810 and 29 ms; kidney medulla, 2100 and 25 ms; subcutaneous tumour, 2365 and 28 ms. This study demonstrates that the zoomed U-FLARE sequence yields single-shot single-slice images with good anatomical resolution and high SNR at 11.7 Tesla. Thus, it offers a viable alternative to standard protocols for mapping very fast parameters, such as T1 and T2, or dynamic processes in vivo at high field. |
| Databáze: | OpenAIRE |
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