Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma
| Autor: | Yang Xu, Yirun Li, Zhou Jiang, Shu Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Lung Neoplasms mRNA Adenocarcinoma of Lung Biology minichromosome maintenance family 03 medical and health sciences 0302 clinical medicine Minichromosome maintenance Gene expression medicine Biomarkers Tumor Humans RNA Messenger database Regulation of gene expression marker Oncogene Minichromosome Maintenance Proteins Gene Expression Profiling General Medicine Articles Cell cycle medicine.disease lung adenocarcinoma Prognosis MCM Protein Gene expression profiling Gene Expression Regulation Neoplastic Survival Rate 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Adenocarcinoma |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| Popis: | The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic value and functions of MCMs in LUAD were investigated using several databases and bioinformatic tools, including Oncomine, GEPIA, cBioPortal, CancerSEA and Kaplan‑Meier plotter. It was demonstrated that the mRNA expression of MCM2, MCM4 and MCM10 were significantly increased in patients with LUAD. High mRNA expression of MCM2‑5, MCM8 and MCM10 were associated with poor overall survival and progression‑free survival. High MCM4 expression was associated with adverse post‑progression survival. In addition, the Human Protein Atlas database showed that MCM protein expression was consistent with the mRNA expression. These results demonstrate that MCM2, MCM4 and MCM10 are potential prognostic markers and therapeutic targets for LUAD. |
| Databáze: | OpenAIRE |
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