Eprosartan-based hypertension therapy, systolic arterial blood pressure and cognitive function: analysis of Middle East data from the OSCAR study
| Autor: | Ghazi Radaideh, Amr Ismail, Patrick Choueiry, Frank Sévenier, Elie Eid, Jean-Pascal Berrou, Armand Sedefdjian, Atul Pathak |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Endocrinology Diabetes and Metabolism Blood Pressure Angiotensin II Type 2 Receptor Blockers Essential hypertension Cognition Pharmacology (medical) Original Research Imidazoles Hematology General Medicine Middle Aged Arabs Pulse pressure Treatment Outcome Acrylates Cohort Cardiology Female Cardiology and Cardiovascular Medicine medicine.drug medicine.medical_specialty hypertension Diastole Subgroup analysis Thiophenes Middle East Internal medicine medicine Humans cognitive function Antihypertensive Agents Aged Psychiatric Status Rating Scales Analysis of Variance Chi-Square Distribution business.industry eprosartan Public Health Environmental and Occupational Health Eprosartan medicine.disease Surgery Vascular Health and Risk Management Logistic Models Blood pressure lcsh:RC666-701 business Chi-squared distribution |
| Zdroj: | Vascular Health and Risk Management Vascular Health and Risk Management, Vol Volume 7, Pp 491-495 (2011) |
| ISSN: | 1178-2048 |
| Popis: | Ghazi Ahmad Radaideh1, Patrick Choueiry2, Amr Ismail2, Elie Eid3, Jean-Pascal Berrou4, Armand Sedefdjian5, Frank Sévenier6, Atul Pathak71Rashid Hospital of Dubai, Dubai, United Arab Emirates; 2Abbott Gulf – Levant; 3Division of Cardiology, American University of Beirut, Beirut, Lebanon; 4Abbott Products Operations AG, Allschwill, Switzerland; 5EvidenceBased Communication (EBC), Rueil-Malmaison, France; 6Fovéa Group, Rueil-Malmaison, France; 7Departments of Clinical Pharmacology and Cardiology, Institut National de la Santé et de la Recherche Médicale U1048, Université de Toulouse-UPS, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceBackground: Studies have indicated a relationship between hypertension and cognitive function. The possible effect of antihypertensive therapy on cognitive disorders is therefore a matter of interest.Materials and methods: The Observational Study on Cognitive function And SBP Reduction (OSCAR) was an open-label, multinational trial designed to evaluate the impact of eprosartan-based antihypertensive therapy on cognitive function in patients with essential hypertension. Eprosartan 600 mg/day for 6 months (with provision for additional medication as needed) was initiated in hypertensive subjects aged ≥50 years. A total of 853 patients in an intention-to-treat cohort from seven countries of the Middle East was identified for subgroup analysis.Results: Arterial blood pressure was reduced significantly (P < 0.001) during the study: At the end of 6 months of eprosartan-based therapy, the mean (±SD) reduction from baseline was 32.1 ± 14.3/14.6.3 ± 8.6 mmHg (P < 0.001). Mean pulse pressure was reduced by 18.3 ± 13.1 mmHg (P < 0.0001 vs baseline). Blood pressure was normalized (systolic |
| Databáze: | OpenAIRE |
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