Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon α-2b and ribavirin
| Autor: | Keisuke Hino, Ayako Nagai, Michiari Okuda, Yasuko Murakami, Takayo Kawakami, Yuh-ichi Hara, Kiwamu Okita, Misako Okita, Akira Kitase |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Ascorbic Acid Interferon alpha-2 Antiviral Agents chemistry.chemical_compound Internal medicine Ribavirin medicine Humans Vitamin E Nutrition and Dietetics Vitamin C business.industry Interferon-alpha Alanine Transaminase Drug Synergism Vitamins Hepatitis C Chronic Middle Aged Viral Load Ascorbic acid Eicosapentaenoic acid Recombinant Proteins Treatment Outcome Endocrinology Eicosapentaenoic Acid chemistry Dietary Supplements Immunology Fatty Acids Unsaturated Leukocytes Mononuclear Drug Therapy Combination Female Arachidonic acid business |
| Zdroj: | Nutrition. 22:114-122 |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/j.nut.2005.05.014 |
| Popis: | Objective We investigated the effects of vitamin E and C supplementation on the fatty acid composition of mononuclear cells and on the clinical observations in patients who had chronic hepatitis C and received interferon-α-2b (IFN-α-2b) and ribavirin combination therapy. Methods Patients were randomly allocated to receive daily 500 mg of vitamin E and 750 mg of vitamin C (vitamin group, n = 14) or no supplement (non-vitamin group, n = 16) in addition to IFN-α-2b and ribavirin therapy. The fatty acid composition of mononuclear cell phospholipids was analyzed before and at 2, 4, and 8 wk after treatment. Results After vitamin supplementation, plasma and red blood cell α-tocopherol and plasma ascorbic acid levels increased in the vitamin group. Serum levels of alanine aminotransferase decreased significantly after 2 wk of treatment in both groups. At the start of treatment, a lower level of eicosapentaenoic acid (EPA) and a higher level of the molar ratio of arachidonic acid to EPA in mononuclear cells were observed in the present patients compared with healthy volunteers, and a significant correlation between the molar ratio and serum alanine aminotransferase level was found. The EPA level of mononuclear cells was maintained in the vitamin group during treatment, whereas a significant decrease was observed in the non-vitamin group at 4 and 8 wk after treatment. Conclusions Antioxidant vitamin supplementation during IFN-α-2b and ribavirin therapy prevented a decrease in EPA of mononuclear cell phospholipids. If a further decrease in the ratio of arachidonic acid to EPA can be achieved by using oral EPA supplementation, the efficacy of IFN-α-2b and ribavirin therapy may be improved. |
| Databáze: | OpenAIRE |
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