Anti-Cancer Activity of Curcumin on Multiple Myeloma
| Autor: | Faezeh Ghasemi, Mohammad Hossein Pourhanifeh, Hossein Bagheri, Philippe Jeandet, Yvan Vander Heyden, Hamed Mirzaei, Haroon Khan, Erfan Mortezapour, Amirhossein Sahebkar, Ali Nikdasti, Jaber M. Khoi |
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| Přispěvatelé: | Résistance Induite et Bioprotection des Plantes - EA 4707 (RIBP), Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Pharmaceutical and Pharmacological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
CRAB features
Curcumin HRQoL multidrug resistance multiple myeloma therapy Cancer Research Cell cycle checkpoint Cell Survival [SDV]Life Sciences [q-bio] 03 medical and health sciences chemistry.chemical_compound Curcuma 0302 clinical medicine medicine Humans Multiple myeloma Cell Proliferation 030304 developmental biology Pharmacology 0303 health sciences Molecular Structure business.industry Cell Cycle Cancer medicine.disease Antineoplastic Agents Phytogenic 3. Good health medicine.anatomical_structure chemistry Apoptosis 030220 oncology & carcinogenesis Monoclonal Cancer research Molecular Medicine Bone marrow Drug Screening Assays Antitumor Signal transduction Multiple Myeloma business |
| Zdroj: | Anti-Cancer Agents in Medicinal Chemistry Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers, 2020, 20, ⟨10.2174/1871520620666200918113625⟩ |
| ISSN: | 1871-5206 1875-5992 |
| DOI: | 10.2174/1871520620666200918113625⟩ |
| Popis: | Multiple Myeloma (MM) is the third most common and deadly hematological malignancy, which is characterized by a progressive monoclonal proliferation within the bone marrow. MM is cytogenetically heterogeneous with numerous genetic and epigenetic alterations, which lead to a wide spectrum of signaling pathways and cell cycle checkpoint aberrations. MM symptoms can be attributed to CRAB features (hyperCalcemia, Renal failure, Anemia, and Bone lesion), which profoundly affect both the Health-Related Quality of Life (HRQoL) and the life expectancy of patients. Despite all enhancement and improvement in therapeutic strategies, MM is almost incurable, and patients suffering from this disease eventually relapse. Curcumin is an active and non-toxic phenolic compound, isolated from the rhizome of Curcuma longa L. It has been widely studied and has a confirmed broad range of therapeutic properties, especially anti-cancer activity, and others, including anti-proliferation, anti-angiogenesis, antioxidant and anti-mutation activities. Curcumin induces apoptosis in cancerous cells and prevents Multidrug Resistance (MDR). Growing evidence concerning the therapeutic properties of curcumin caused a pharmacological impact on MM. It is confirmed that curcumin interferes with various signaling pathways and cell cycle checkpoints, and with oncogenes. In this paper, we summarized the anti- MM effects of curcumin. |
| Databáze: | OpenAIRE |
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