Temporal and Dose-Dependent Relationships between In Vivo B Cell Receptor-Targeted Proliferation and Deletion-Induced by a Microbial B Cell Toxin

Autor: Fujimi Sugiyama, Carl S. Goodyear, Gregg J. Silverman
Rok vydání: 2006
Předmět:
Zdroj: The Journal of Immunology. 176:2262-2271
ISSN: 1550-6606
0022-1767
DOI: 10.4049/jimmunol.176.4.2262
Popis: The effective functioning of the adaptive immune system requires careful clonal regulation within the B cell compartment. Some microbial pathogens produce virulence factors, like staphylococcal protein A, which interact at high frequencies with B lymphocyte through unconventional binding sites in BCR variable region frameworks conserved during evolution. We have characterized the in vivo effect of staphylococcal protein A treatment on peripheral B cells bearing susceptible BCR, and found a dose-dependent direct relationship over the range of 2 mg to
Databáze: OpenAIRE