Temporal and Dose-Dependent Relationships between In Vivo B Cell Receptor-Targeted Proliferation and Deletion-Induced by a Microbial B Cell Toxin
Autor: | Fujimi Sugiyama, Carl S. Goodyear, Gregg J. Silverman |
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Rok vydání: | 2006 |
Předmět: |
Time Factors
Lymphocyte Immunology B-cell receptor Receptors Antigen B-Cell Biology Mice In vivo medicine Superantigen Animals Immunology and Allergy Staphylococcal Protein A Receptor Cells Cultured B cell Cell Proliferation B-Lymphocytes Superantigens Dose-Response Relationship Drug breakpoint cluster region Acquired immune system Molecular biology medicine.anatomical_structure Immunoglobulin M Injections Intravenous |
Zdroj: | The Journal of Immunology. 176:2262-2271 |
ISSN: | 1550-6606 0022-1767 |
DOI: | 10.4049/jimmunol.176.4.2262 |
Popis: | The effective functioning of the adaptive immune system requires careful clonal regulation within the B cell compartment. Some microbial pathogens produce virulence factors, like staphylococcal protein A, which interact at high frequencies with B lymphocyte through unconventional binding sites in BCR variable region frameworks conserved during evolution. We have characterized the in vivo effect of staphylococcal protein A treatment on peripheral B cells bearing susceptible BCR, and found a dose-dependent direct relationship over the range of 2 mg to |
Databáze: | OpenAIRE |
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