Hypothalamic hypopituitarism in a patient with a basal encephalocoele—treatment with luteinizing hormone-releasing hormone
| Autor: | J. Adams, W. P. Mason, J. Tanner, Howard S. Jacobs, N. Wilson-Holt, D. V. Morris, M. Keene |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty media_common.quotation_subject Gonadotropin-releasing hormone Hypopituitarism Gonadotropic cell Hypothalamic disease Growth hormone deficiency Gonadotropin-Releasing Hormone Internal medicine medicine Humans Amenorrhea Ovulation Encephalocele media_common business.industry Hypogonadism General Medicine medicine.disease Endocrinology Growth Hormone Female business Luteinizing hormone Diabetes Insipidus Hypothalamic Diseases hormones hormone substitutes and hormone antagonists Research Article Endocrine gland |
| Zdroj: | Postgraduate Medical Journal. 60:597-604 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.60.707.597 |
| Popis: | Summary A 20-year-old patient presented with primary amenorrhoea and growth hormone deficiency caused by a basal encephalocoele. She was found to have developed diabetes insipidus in the 8 years following diagnosis. Gonadotrophin release in response to bolus injection of luteinizing hormone-releasing hormone (LHRH) was normal, as was thyrotrophin and adrenocorticotrophin (ACTH) secretion. Pulsatile administration of LHRH by the subcutaneous route resulted in normal ovulation and subsequent menstruation. The investigation and management of patients with basal encephalocoeles are discussed in the light of these findings. |
| Databáze: | OpenAIRE |
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