A case of systemic pseudo-pseudoxanthoma elasticum with diverse symptomatology caused by long-term penicillamine use
| Autor: | G N Antonakopoulos, R M Cayton, S J Darnton, A P Coatesworth, R. Green |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Pathology Connective tissue Drug Administration Schedule Pathology and Forensic Medicine Hepatolenticular Degeneration Biopsy medicine Humans Pseudoxanthoma Elasticum Chelating Agents Lung medicine.diagnostic_test business.industry Penicillamine General Medicine Middle Aged Pseudoxanthoma elasticum medicine.disease Dysphagia Dermatology medicine.anatomical_structure Cricopharyngeal myotomy medicine.symptom Abnormality business Research Article medicine.drug |
| Zdroj: | Journal of Clinical Pathology. 51:169-171 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.51.2.169 |
| Popis: | A 47 year old man presented with a two year history of increasing cervical dysphagia, dyspnoea, and cutaneous signs. He had been diagnosed 27 years previously with Wilson's disease and was treated with penicillamine (1.5 g daily). Systemic abnormality of elastic fibres was confirmed by light and electron microscopy following biopsy of skin, lung, oesophageal muscle, gum, pharyngeal tissue, and cervical connective tissue. Dysphagia was relieved by cricopharyngeal myotomy. Substitution of trientene dihydrochloride for penicillamine relieved cutaneous and systemic manifestations. This is possibly the first case demonstrating an association between prolonged penicillamine use and biopsy proved systemic pseudo-pseudoxanthoma elasticum. The presenting symptoms may have resulted from the abnormal numbers and properties of elastic fibres, and the changes were caused by penicillamine use, rather than by idiopathic, inherited pseudoxanthoma elasticum. |
| Databáze: | OpenAIRE |
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