Zinc nutritional status, androgens, and growth retardation
| Autor: | Vaddanahally T. Maddaiah, S. Chen, Thulasi Cheruvanky, Mariano Castro-Magana, Platon J. Collipp |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Secondary sex characteristic chemistry.chemical_element Zinc Constitutional growth delay Genitalia Male Oral administration Internal medicine Methyltestosterone Medicine Humans Sex organ Testosterone Child Growth Disorders business.industry Hair analysis Endocrinology chemistry Pediatrics Perinatology and Child Health business medicine.drug Hair |
| Zdroj: | American journal of diseases of children (1960). 135(4) |
| ISSN: | 0002-922X |
| Popis: | Zinc levels were measured in hair and serum of boys with constitutional growth delay and familial short status and in several boys before and after oral administration of methyltestosterone. These results show the following: (1) zinc levels in boys beyond stage 3 of genital development are significantly higher than in stage 1 and 2; (2) there is a linear relationship between zinc levels and serum testosterone concentration (up to 250 ng/dL); and (3) methyltestosterone administration raised the zinc concentration in serum and hair, especially in boys with constitutional growth delay. Therefore, increased endogenous production or exogenous supply of testosterone are associated with increased zinc levels. We speculate that the relative testosterone deficiency and hypogonadotropism seen in constitutional growth delay may result in decreased zinc levels, which in turn could cause a further delay in the appearance of secondary sexual characteristics and greater growth retardation. |
| Databáze: | OpenAIRE |
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