Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
Autor: | Jürgen Gallinat, Malek Bajbouj, Georg Winterer, Undine E. Lang, Falk W. Lohoff, Thomas Sander, Rainer Hellweg |
---|---|
Rok vydání: | 2006 |
Předmět: |
Adult
Male medicine.medical_specialty Genotype media_common.quotation_subject Mutation Missense Polymorphism Single Nucleotide Risk Assessment Nicotine Methionine Gene Frequency Neurotrophic factors Polymorphism (computer science) Reference Values Internal medicine Germany Surveys and Questionnaires medicine Humans Genetic Predisposition to Disease Allele Psychiatry Allele frequency media_common Aged Pharmacology Brain-derived neurotrophic factor Analysis of Variance Addiction Brain-Derived Neurotrophic Factor Smoking Valine Tobacco Use Disorder Middle Aged Endocrinology Female Psychology medicine.drug Addiction vulnerability |
Zdroj: | Psychopharmacology. 190(4) |
ISSN: | 0033-3158 |
Popis: | It has been suggested that a susceptibility locus near the gene encoding the brain-derived neurotrophic factor (BDNF) contributes to individual differences in human addiction vulnerability. BDNF modulates several behaviors that are associated with addictive drugs, and upregulation of BDNF was found to be associated with several drugs of abuse such as amphetamine, cocaine, and nicotine. In this study, we addressed the question if a common BDNF missense variation (Val66Met) influences the risk for smoking behavior in otherwise healthy human volunteers. In total, 320 healthy unrelated volunteers (155 male, 165 female, mean age: 38.4 ± 14.1 years) consisting of 43.3% never smokers, 20.9% former smokers, and 35.6% current smokers were investigated. The frequency of both Met/Met genotype and Met allele was significantly increased in current and in former smokers when compared to never smokers (χ 2 = 10.856, df = 2, p = 0.004 and χ 2 = 4.350, df = 1, p = 0.045, respectively). Our results suggest that humans who carry the Met allele of the BDNF missense polymorphism might be more vulnerable to initiate and also maintain smoking. |
Databáze: | OpenAIRE |
Externí odkaz: |