Dietary Intake of Antioxidant Vitamins and Carotenoids and Risk of Developing Active Tuberculosis in a Prospective Population-Based Cohort Study
| Autor: | Woon-Puay Koh, Cynthia B.E. Chee, Yee-Tang Wang, Jian-Min Yuan, Avril Z. Soh |
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| Rok vydání: | 2017 |
| Předmět: |
Vitamin
medicine.medical_specialty Tuberculosis Vitamin C Epidemiology business.industry Original Contributions Incidence (epidemiology) Retinol 030209 endocrinology & metabolism Ascorbic acid medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Internal medicine Cohort medicine 030212 general & internal medicine business Prospective cohort study |
| Zdroj: | American Journal of Epidemiology. 186:491-500 |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | Antioxidants may protect against oxidative stress, which is associated with tuberculosis (TB) disease. However, direct evidence for a protective association between dietary antioxidants and TB incidence in humans has been lacking. The relationship between intake of antioxidant vitamins (vitamins A, C, D, and E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein) and TB incidence was examined in the Singapore Chinese Health Study, a prospective cohort study of 63,257 adults aged 45-74 years enrolled during 1993-1998. Baseline intake of these antioxidants was estimated using a validated semiquantitative food frequency questionnaire including questions on use of dietary supplements. After an average of 16.9 years of follow-up, 1,186 incident active TB cases were identified among cohort participants. Compared with the lowest quartile, reduced risk of active TB was observed for the highest quartile of vitamin A intake (hazard ratio = 0.71, 95% confidence interval: 0.59, 0.85; P-trend |
| Databáze: | OpenAIRE |
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