Liver damage in bleomycin-induced pulmonary fibrosis in mice
| Autor: | Sergio R. Aguilar-Ruiz, Rafael Baltiérrez-Hoyos, Verónica R. Vásquez-Garzón, A Ramírez-Cosmes, L Pérez-Campos Mayoral, Sergio Hernández-García, Honorio Torres-Aguilar, Jaime Arellanes-Robledo, Socorro Pina-Canseco, Gabriela Carrasco-Torres, Juan José Alpuche, Saúl Villa-Treviño, Edilburga Reyes-Jiménez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Cirrhosis Pulmonary Fibrosis Inflammation Protein oxidation Bleomycin Antigens CD1 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Fibrosis Proliferating Cell Nuclear Antigen Pulmonary fibrosis medicine Animals Lung Skin Pharmacology Autoimmune disease Scleroderma Systemic business.industry Liver Diseases Cancer General Medicine medicine.disease Actins Disease Models Animal 030104 developmental biology Ki-67 Antigen chemistry Liver 030220 oncology & carcinogenesis Collagen medicine.symptom business |
| Zdroj: | Naunyn-Schmiedeberg's archives of pharmacology. 392(12) |
| ISSN: | 1432-1912 |
| Popis: | Pulmonary fibrosis is an emerging disease with a poor prognosis and high mortality rate that is even surpassing some types of cancer. This disease has been linked to the concomitant appearance of liver cirrhosis. Bleomycin-induced pulmonary fibrosis is a widely used mouse model that mimics the histopathological and biochemical features of human systemic sclerosis, an autoimmune disease that is associated with inflammation and expressed in several corporal systems as fibrosis or other alterations. To determine the effects on proliferation, redox and inflammation protein expression markers were analyzed by immunohistochemistry. Analyses showed a significant increase in protein oxidation levels by lipoperoxidation bio-products and in proliferation and inflammation processes. These phenomena were associated with the induction of the redox status in mice subjected to 100 U/kg bleomycin. These findings clearly show that the bleomycin model induces histopathological alterations in the liver and partially reproduces the complexity of systemic sclerosis. Our results using the bleomycin-induced pulmonary fibrosis model provide a protocol to investigate the mechanism underlying the molecular alteration found in the liver linked to systemic sclerosis. |
| Databáze: | OpenAIRE |
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