Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases
| Autor: | József Furák, Balazs Dome, János Fillinger, Zsuzsanna Németh, László Tiszlavicz, Katalin Fábián, Márta Jäckel, Zsuzsa Schaff, Krisztina Bogos, Judit Moldvay |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Prognostic factor Pathology medicine.medical_specialty Lung Neoplasms Cell Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung Claudin-1 medicine Humans Lung cancer Claudin Aged biology CLDN3 General Medicine Middle Aged medicine.disease Prognosis body regions Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis biology.protein Carcinoma Squamous Cell Immunohistochemistry Female Non small cell Antibody |
| Zdroj: | Pathology oncology research : POR. 23(1) |
| ISSN: | 1532-2807 |
| Popis: | The aim of the study was to investigate the correlation between claudin (CLDN) protein expression and clinicopathological parameters as well as survival in histological subtypes of non-small cell lung cancer. Archived surgical resection specimens of 137 pathologic stage I primary bronchial cancers including 49 adenocarcinomas of non-lepidic variants (ADC), 46 adenocarcinomas of lepidic variants (L-ADC), and 42 squamous cell carcinomas (SCC) were examined. Immunohistochemistry (IHC) using antibodies against CLDN1,-2,-3,-4,-7 proteins as well as semiquantitative estimation (IHC scores 0–5) were performed. Claudin IHC scores of L-ADC differed significantly from ADC (CLDN1: p = 0.009, CLDN2: p = 0.005, CLDN3: p = 0.004, CLDN4: p = 0.001, CLDN7: p |
| Databáze: | OpenAIRE |
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