Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD
Autor: | N. A. Maslatsov, Ivan S. Murashov, Viktoria S. Shramko, Elena V. Kashtanova, Y. Polonskaya, Aleksandr M. Chernyavsky, Alexey V. Kurguzov, Yulia Ragino, E.M. Stakhneva, Evgenia V. Striukova |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) 030204 cardiovascular system & hematology Article metalloproteinases calcification 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Internal medicine medicine Osteopontin coronary heart disease Endarterectomy biology business.industry medicine.disease multiplex assay Coronary arteries 030104 developmental biology medicine.anatomical_structure biology.protein Osteocalcin Cardiology Medicine Osteonectin atherosclerosis business Calcification Blood vessel |
Zdroj: | Journal of Personalized Medicine Volume 11 Issue 6 Journal of Personalized Medicine, Vol 11, Iss 506, p 506 (2021) |
ISSN: | 2075-4426 |
Popis: | This work is aimed at studying the relationship of matrix metalloproteinases with calcification of the coronary arteries. The study included 78 people with coronary heart disease (CHD) and 36 without CHD. Blood and samples of coronary arteries obtained as a result of endarterectomy were examined. Serum levels of metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, and MMP-13 were determined by multiplex analysis. In blood vessel samples, MMP-1, MMP-3, MMP-7, and MMP-9 were determined by enzyme immunoassay MMP-9 expression was evaluated by immunohistochemistry. Patients with CHD had higher serum levels of MMP-1, MMP-7, and MMP-12. Blood levels of MMP-1 and MMP-3 were associated with calcium levels, MMP-9 with osteoprotegerin and osteonectin, MMP-7 and MMP-10 with osteoprotegerin, MMP-12 with osteocalcin, and MMP-13 with osteopontin. Calcified plaques had higher levels of MMP-1 and MMP-9 compared to plaques without calcification. The relative risk of coronary arteries calcification was associated with MMP-9, which is confirmed by the results of immunohistochemistry. The results obtained indicate the participation of some MMPs, and especially MMP-9, in the calcification processes. The study can serve as a basis for the further study of the possibility of using MMP-1, MMP-7 and MMP-12 as potential biomarkers of CHD. |
Databáze: | OpenAIRE |
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