Biological effects of high-frequency ultrasound exposure during mouse organogenesis
| Autor: | Viviene Cucevic, Allison S. Brown, F. Stuart Foster, Angela D Reid, Lisa Leamen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Biometry Litter Size Acoustics and Ultrasonics Offspring Microscopy Acoustic Biophysics Operating frequency Ultrasound biomicroscopy Gestational Age Mice Inbred Strains Organogenesis Body Temperature Fetal Development Andrology Mice Pregnancy medicine Animals Ultrasonics Radiology Nuclear Medicine and imaging Radiological and Ultrasound Technology business.industry Body Weight Ultrasound Significant difference Ultrasonography Doppler Surgery Female business High frequency ultrasound |
| Zdroj: | Ultrasound in Medicine & Biology. 30:1223-1232 |
| ISSN: | 0301-5629 |
| Popis: | Little has been reported on bioeffects of high-frequency ultrasound (US) and guidelines for US use do not necessarily apply to high frequencies. Pregnant CD-1 mice were exposed to Doppler or B-mode US biomicroscopy (UBM) on embryonic day (E) 8.5 or E10.5, during organogenesis. Operating frequency was 40 MHz with a free field I SPTA of 11.9 W/cm 2 (Doppler) and 2.6 mW/cm 2 (B-mode), peak negative pressures of 6.61 MPa and MI of 1.05 (B-mode). Offspring were assessed weekly from 1 day postnatally to euthanasia at 6 weeks, with no significant difference in pup weight, body length or crown-rump length observed. E8.5 Doppler-exposed mice showed a small reduction in weight and length at 3 weeks and in weight at 6 weeks. E10.5 Doppler-exposed animals exhibited slight growth reduction in weeks 2 to 4, but were not significantly different at 6 weeks. Our results indicate similar exposures of mice should not cause significant adverse bioeffects. (E-mail: aduckett@sten.sunnybrook.utoronto.ca ) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|