Polymeric mixed micelles as nanomedicines: Achievements and perspectives
| Autor: | Fiorella Carla Tesan, Marcela Zubillaga, María J. Salgueiro, Maximiliano Cagel, Ezequiel Bernabeu, Marcela A. Moretton, Diego A. Chiappetta |
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| Rok vydání: | 2017 |
| Předmět: |
IMAGING TECHNIQUES
Farmacología y Farmacia CIENCIAS MÉDICAS Y DE LA SALUD Materials science Polymers Pharmaceutical Science Nanotechnology macromolecular substances 02 engineering and technology NANOMEDICINES 010402 general chemistry 01 natural sciences Micelle PRECLINICAL STUDIES Micelles PHARMACEUTICAL APPLICATIONS Drug Carriers Polymeric micelles General Medicine CENTRAL NERVOUS SYSTEM DISEASES 021001 nanoscience & nanotechnology CANCER 0104 chemical sciences Medicina Básica Nanomedicine Drug delivery HIV/AIDS Nanocarriers 0210 nano-technology CLINICAL TRIALS POLYMERIC MIXED MICELLES Biotechnology |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 113:211-228 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/j.ejpb.2016.12.019 |
| Popis: | During the past few decades, polymeric micelles have raised special attention as novel nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous diseases. These nanocarriers exhibit several in vitro and in vivo advantages as well as increased stability and solubility to hydrophobic drugs. An interesting approach for optimizing these properties and overcoming some of their disadvantages is the combination of two or more polymers in order to assemble polymeric mixed micelles. This review article gives an overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles. Besides, the present article presents relevant research outcomes about polymeric mixed micelles as better drug delivery systems, when compared to polymeric pristine micelles. The reported data clearly illustrates the promise of these nanovehicles reaching clinical stages in the near future. Fil: Cagel, Carlos Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina Fil: Bernabeu, Ezequiel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina |
| Databáze: | OpenAIRE |
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