Effects of fluvastatin therapy on serum interleukin-18 and interleukin-10 levels in patients with acute coronary syndrome
| Autor: | Rui Zhu, Bin Li, Yong-sheng Liu, Wenwei Liu, Hong Jiang, Yongqian Tang, Hongling Shang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Indoles Blood lipids Enzyme-Linked Immunosorbent Assay Inflammation Placebo Group A Angina Pectoris Fatty Acids Monounsaturated Internal medicine medicine Humans Acute Coronary Syndrome Fluvastatin business.industry Interleukin-18 Case-control study General Medicine Middle Aged medicine.disease Lipids Interleukin-10 Treatment Outcome Case-Control Studies Cardiology Female Interleukin 18 Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Acta Cardiologica. 65:285-289 |
| ISSN: | 0001-5385 |
| DOI: | 10.2143/ac.65.3.2050343 |
| Popis: | Objective — Experimental data demonstrate that inflammation plays an important role in the initiation, progression, and complications of atherosclerosis. Statins were shown to downregulate inflammatory cytokines.We conducted this study to investigate the effects of fluvastatin therapy on plasma interleukin-18 (IL-18) and interleukin-10 (IL-10) concentration in patients with acute coronary syndrome. Methods and results — Serum IL-18 and IL-10 levels were measured in 90 patients with acute coronary syndrome, 47 patients with stable angina pectoris, and 55 normal control subjects. Patients in the acute coronary syndrome group were randomly assigned to a fluvastatin group and a routine group. The fluvastatin group was given fluvastatin 40 mg/day and the routine group a placebo. After one month of follow-up, serum IL-18, IL-10 levels, and serum lipid concentration were measured again. Serum IL-18 levels were significantly higher in the acute coronary syndrome group than in the stable angina pectoris group and the control group. However, serum IL-10 levels were significantly lower than in the stable angina pectoris group and the control group. After one month of treatment, the serum IL-18 levels decreased significantly and the serum IL-10 levels increased significantly in all patients with acute coronary syndrome, but the changes of serum IL-18 and IL-10 levels were more pronounced in the fluvastatin group. No relationship was observed between the rate of decrease of serum IL-18 or the rate of increase of serum IL-10 and serum lipids levels. Conclusion — Inflammation plays an important role in the initiation of acute coronary syndromes. Fluvastatin possesses an anti-inflammatory effect, independent of its lipid-lowering action. |
| Databáze: | OpenAIRE |
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