The bonding of anesthetics and antibiotics on the carboxymethylcellulose
Autor: | V Nadezda Iliskovic, Branka B. Rodić-Grabovac, M Radana Djudjic |
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Rok vydání: | 2007 |
Předmět: |
carboxymethyl cellulose
medicine.drug_class General Chemical Engineering biologically active material chemotherapeutic binding Antibiotics Procaine Hydrochloride Chemical modification Sorption General Chemistry lcsh:Chemical technology Carboxymethyl cellulose chemistry.chemical_compound chemistry Desorption Anesthetic medicine Organic chemistry lcsh:TP1-1185 Cellulose medicine.drug |
Zdroj: | Hemijska Industrija, Vol 61, Iss 4, Pp 203-207 (2007) |
ISSN: | 2217-7426 0367-598X |
Popis: | The preparation of biologically active material is one of the most interesting trends in the chemical modification of cellulose. The possibility of obtaining biologically active cellulosic material by sorption of procaine hydrochloride and gentamicin sulphate on CMC was investigated in this paper. The sorption of therapeutics on CMC samples with different degree of substitution was carried out in water solutions of anesthetic and antibiotic, while the desorption was done in 0.95% NaCl solution. The amount of bonded and released therapeutics was determined by UV spe-ctrophotometry. It was found that degree of substitution of car-boxymethylcellulose and concentration of chemotherapeutic water solution have significant influence on the amount of bonded anesthetic and antibiotic. The maximum amount of bonded chemotherapeutic was 72.15 mg of procaine hydrochloride and 165.49 mg of gentamicin sulphate per gram CMC. In both cases the amounts of bonded chemotherape-utics correspond to the concentration of local anesthetic and antibiotic preparation that are used in therapeutic purposes. |
Databáze: | OpenAIRE |
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