Tuberculosis Burden among Household Pediatric Contacts of Adult Tuberculosis Patients
| Autor: | Dipti Agarwal, C Bipin, Ankur Goyal, Rajeshwar Dayal, Shamrendra Narayan, Santosh Kumar, Neeraj Kumar Yadav, Rakesh Bhatia |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Adolescent Cross-sectional study 030231 tropical medicine Tuberculin India Nutritional Status Disease Drug resistance 03 medical and health sciences 0302 clinical medicine Sex Factors Latent Tuberculosis 030225 pediatrics Internal medicine Tuberculosis Multidrug-Resistant medicine Prevalence Humans Child Family Characteristics Latent tuberculosis business.industry Transmission (medicine) medicine.disease Cross-Sectional Studies Socioeconomic Factors Child Preschool Pediatrics Perinatology and Child Health BCG Vaccine Female business BCG vaccine |
| Zdroj: | Indian journal of pediatrics. 85(10) |
| ISSN: | 0973-7693 |
| Popis: | To find out the prevalence of latent tuberculosis (TB) infection and TB disease among pediatric household contacts of adult drug resistant (MDR) and drug susceptible (DS) TB patients and to identify the risk factors for occurrence of TB infection in the contacts. Pediatric household contacts (less than 15 y age) of adult TB patients (both MDR and DS) were included in the study. They were categorized as latent TB infection (LTBI), TB disease and TB exposed based on the results of tuberculin skin testing (TST), clinical examination and chest X-ray. Various factors (age, gender, socioeconomic status, BCG immunization etc.) were evaluated to assess their association with TB transmission. A total of 271 household contacts were included in the study. Prevalence of LTBI was 20.3% (31% in MDR TB group and 14% in DS TB group); difference was significant (p value = 0.0018). TB disease was seen in 3 subjects in DS group while none in MDR group developed TB disease. Lower socioeconomic status was significantly associated with risk of TB infection in MDR group (p value =0.0027). In DS TB group, male gender, BCG non-immunization was significantly associated with risk of developing TB (p value 0.0068 and 0.0167 respectively). Prevalence of latent TB infection was found to be high in household pediatric contacts especially in contacts of MDR TB patients. Risk factors identified for occurrence of TB included lower socioeconomic status, BCG non-immunization and male gender. The study focuses on the importance of contact screening and the need for its implementation in TB control programs. |
| Databáze: | OpenAIRE |
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