Risk of infections and cardiovascular and venous thromboembolic events associated with JAK inhibitors in rheumatoid arthritis: protocols of two systematic reviews and network meta-analyses
| Autor: | Christian E Gunning, William B MacLeod, Magdalene Mwale, Donald M Thea, Rachel C Pieciak, Pejman Rohani |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Tuberculosis Network Meta-Analysis law.invention Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Meta-Analysis as Topic law Internal medicine Epidemiology Humans Janus Kinase Inhibitors Medicine 030212 general & internal medicine Intensive care medicine Venous Thrombosis Clinical pharmacology business.industry Venous Thromboembolism General Medicine medicine.disease Systematic review Network Meta-Analyses Rheumatoid arthritis epidemiology clinical pharmacology business Venous thromboembolism 030217 neurology & neurosurgery Systematic Reviews as Topic |
| Zdroj: | BMJ Open, Vol 10, Iss 12 (2020) BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2020-041420 |
| Popis: | IntroductionJanus kinases (JAK) inhibitors demonstrated to be effective in the treatment of adult patients with moderate-to-severe active rheumatoid arthritis (RA) but have been associated with serious cardiovascular and serious events. Two systematic reviews and network meta-analyses will be carried aiming to compare the relative safety of the different JAK inhibitors with regard to the risk of (1) cardiovascular and thromboembolic events and (2) serious infections in patients with RA.Methods and analysisPUBMED, Embase, Cochrane Controlled Register of Trials and ClinicalTrials.gov will be searched in order to identify randomised controlled trials evaluating the efficacy and safety of JAK inhibitors in patients with RA. The following events will be assessed: (1) any cardiovascular event; major adverse cardiovascular events and venous thromboembolism and (2) any infection; serious infections; herpes zoster infection and tuberculosis. Search terms will comprise RA and drugs names, including the thesaurus terms and the International Nonproprietary Names. The assessment of the methodological quality of the included studies will be performed through the RoB 2 tool: a revised Cochrane risk of bias tool for randomised trials. Network meta-analyses will be performed using STATA V.13.0. For each outcome, treatments will be ranked according to the probability of being the safest (best) alternative using the surface under the cumulative ranking curve.Ethics and disseminationEthical approval is not required as no primary data are collected. This systematic review will be disseminated through peer-reviewed publications and at conference meetings. |
| Databáze: | OpenAIRE |
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