The effect of estrogen in coronavirus disease 2019
| Autor: | Qing Ma, Yan-Feng Wang, Zhuo-Wen Hao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Coronavirus disease 2019 (COVID-19) Physiology medicine.drug_class sex difference Review Adaptive Immunity immune response Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Physiology (medical) estrogen medicine Humans Sex Characteristics High prevalence SARS-CoV-2 Mechanism (biology) business.industry COVID-19 Estrogens Cell Biology Acquired immune system Immunity Innate 030104 developmental biology Estrogen Female business 030217 neurology & neurosurgery Sex characteristics |
| Zdroj: | American Journal of Physiology-Lung Cellular and Molecular Physiology |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00332.2020 |
| Popis: | The outcomes of coronavirus disease 2019 (COVID-19) vary between men and women. Some statistical reports have shown that men have a higher risk of developing COVID-19 and suffer from worse outcomes than females. Although there are many factors that can explain the high prevalence of COVID-19 in men, such as lifestyle habits and the different profile of comorbidities among sexes, the distinctions between male and female immune systems cannot be ignored. It has been sufficiently shown that sex differences have a critical influence on the shaping of immune response, which then leads to different pathogenesis in infectious diseases. Compared with males, females typically have a more effective innate and adaptive immune response to viral infections in COVID-19. What’s more, there is a growing body of evidence showing that estrogen exerts an effect on the regulation of immune response. This article examines the effect and mechanism of estrogen on COVID-19. |
| Databáze: | OpenAIRE |
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