Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial
| Autor: | Li-Ya Su, Shu-Rong Liu, Lei Zhang, Dong-Hai Wang, Yanan Yu, Zhi-Wei Jing, Si-Yuan Hu, Jian-Yuan Tang, Yongyan Wang, Zhuo-Ming Li, Bo Dong, Guo-Xin Li, Jun Liu, Qiguang Chen, Bi-Wei Chen, Wei Lu, Xiang-Ling Liu, Zhong Wang, Li-Ying Wang, Xiao-Feng Wang, Song-Shan Liu, Hongli Wu, Chun-Ti Shen, Jie Xue, Xi-Yan Yang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures Ecchymosis Capsules Salvia miltiorrhiza Gastroenterology law.invention Angina Double-Blind Method Randomized controlled trial Tongue law Internal medicine medicine Palpitations Humans Angina Stable Medicine Chinese Traditional Aged Pharmacology business.industry Capsule Middle Aged medicine.disease Phenotype Surgery NONMEM Treatment Outcome medicine.anatomical_structure Data Interpretation Statistical medicine.symptom Cardiology and Cardiovascular Medicine business Drugs Chinese Herbal |
| Zdroj: | Current Vascular Pharmacology. 13:492-503 |
| ISSN: | 1570-1611 |
| DOI: | 10.2174/1570161112666141014151858 |
| Popis: | Objective: To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment. Methods: Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling (NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest, palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on Days 0, 14, 28, 42, and 56. Results: Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group. Conclusion: Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic variation of SAP may be determined, to improve the development and modification of treatment regimens. |
| Databáze: | OpenAIRE |
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