Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice
| Autor: | Hainan Ji, Naining Song, Juan Ren, Haishan Li, Wentao Li, Guolin Shen, Baoliang Xu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Environmental Engineering 010504 meteorology & atmospheric sciences 010501 environmental sciences Hypoglycemia Carbohydrate metabolism Endocrine Disruptors 01 natural sciences Mice Phenols Internal medicine medicine Environmental Chemistry Animals Metabolomics Glycolysis Benzhydryl Compounds Liver X receptor Waste Management and Disposal 0105 earth and related environmental sciences chemistry.chemical_classification urogenital system Fatty acid medicine.disease Pollution Citric acid cycle Mice Inbred C57BL Molecular Docking Simulation Endocrinology Enzyme Glucose chemistry Nuclear receptor Liver hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Science of the total environment. 703 |
| ISSN: | 1879-1026 |
| Popis: | Bisphenol-A (BPA) is a representative environmental endocrine disrupting chemical that is widely used in the production of polycarbonate plastics and epoxy resins. Many studies have confirmed BPA to be closely associated with metabolic diseases, reproductive system diseases, and sex hormone-dependent cancers. In this study, we aimed to systematically elucidate the molecular action of BPA on liver fatty acid and glucose metabolism and the reasons for BPA-induced hypoglycemia through a metabonomics approach. C57BL/6 mice were orally treated with BPA (1, 10, 50, 250 μg/kg) for 35 days and the liver metabonomics and histopathology, molecular docking, mRNA expression levels and activities of enzymes were analyzed. Based on the high-resolution mass spectrometry (MS) for metabonomics and on various software and bioinformatic analysis methods, we found that BPA could affect fatty acid and glucose metabolism, block the TCA cycle, and BPA also regulated the nuclear receptor LXR caused hypoglycemia, thereby affecting the normal metabolic functions of the liver. |
| Databáze: | OpenAIRE |
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