Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism
| Autor: | Yongnan Xu, Hui-Ming Hua, Haonan Li, Jinyi Xu, Xu Hu, Xiang Gao, Dahong Li, Shengtao Xu, Baojia Sun, Mingying Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Phytochemistry
Synthetic derivatives Stereochemistry Pharmacology toxicology Apoptosis Microbial Sensitivity Tests 01 natural sciences chemistry.chemical_compound Anti-Infective Agents Cell Line Tumor Drug Discovery Animals Humans Ent kaurane Cell Proliferation Biological Products Natural product Molecular Structure 010405 organic chemistry Organic Chemistry Antineoplastic Agents Phytogenic Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Drug Design Molecular Medicine Diterpenes Pharmacophore Diterpenes Kaurane |
| Zdroj: | Archives of Pharmacal Research. 41:1051-1061 |
| ISSN: | 1976-3786 0253-6269 |
| Popis: | Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also designed and synthesized with promising therapeutic effects. Among the hopefuls, enmein-type 6,7-seco-ent-kaurane diterpenoids with unique ring system and stereogenic centers exhibit attractive activities. Based on their lead-like properties, enmein-type diterpenoids are suitable for further medicinal study. The derivatives were biologically evaluated and showed promising activities, which warranted in-depth research for further understanding. In this review, the natural bioactive enmein-type diterpenoids and the synthetic derivatives were comprehensively summarized. |
| Databáze: | OpenAIRE |
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