Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients
| Autor: | Animesh Pardanani, Naseema Gangat, A Tefferi, C A Hanson, Kebede H. Begna, Domenica Caramazza, Rakhee Vaidya, D L Van Dyke, Sergio Siragusa |
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| Přispěvatelé: | Caramazza, D, Begna, K, Gangat, N, Vaidya, R, Siragusa, S, Van Dyke, D, Hanson, C, Pardanani, A, Tefferi, A |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Risk Cancer Research medicine.medical_specialty Pathology Adolescent Chromosomal translocation myelofibrosis Gastroenterology cytogenetics Disease-Free Survival Settore MED/15 - Malattie Del Sangue Internal medicine Complex Karyotype medicine Humans Myelofibrosis Aged Aged 80 and over Chromosome Aberrations Leukemia Hematology Platelet Count business.industry Hazard ratio Karyotype Middle Aged Prognosis medicine.disease Confidence interval karyotype Oncology Primary Myelofibrosis International Prognostic Scoring System Karyotyping Original Article Female myeloproliferative business |
| Zdroj: | Leukemia |
| Popis: | We have previously identified sole +9, 13q- or 20q-, as 'favorable' and sole +8 or complex karyotype as 'unfavorable' cytogenetic abnormalities in primary myelofibrosis (PMF). In this study of 433 PMF patients, we describe additional sole abnormalities with favorable (chromosome 1 translocations/duplications) or unfavorable (-7/7q-) prognosis and also show that other sole or two abnormalities that do not include i(17q), -5/5q-, 12p-, inv(3) or 11q23 rearrangement are prognostically aligned with normal karyotype, which is prognostically favorable. These findings were incorporated into a refined two-tired cytogenetic-risk stratification: unfavorable and favorable karyotype. The respective 5-year survival rates were 8 and 51% (hazard ratio (HR): 3.1, 95% confidence interval (CI): 2.2-4.3; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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