Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors

Autor:	Caroline Jeanne Margaret Rockell, Lee James Beeley, Paul W. Young, Helen Chapman, Diane P. Naselsky, Paul Hieble, John M. Berge, John Kelly
Rok vydání:	1995
Předmět:	Blood Platelets Indoles Magnetic Resonance Spectroscopy Adrenergic receptor Clinical Biochemistry Pharmaceutical Science Alpha (ethology) CHO Cells Pharmacology In Vitro Techniques Isoindoles Biochemistry Receptors Adrenergic alpha-2 Cricetinae Drug Discovery Animals Humans Cloning Molecular Molecular Biology Adrenergic alpha-Antagonists Aorta Cerebral Cortex Molecular Structure Chemistry Organic Chemistry Antagonist Imidazoles Stereoisomerism Adrenergic alpha-2 Receptor Antagonists Recombinant Proteins Rats Adipose Tissue Molecular Medicine Alpha adrenoceptor Rabbits
Zdroj:	Bioorganicmedicinal chemistry. 3(12)
ISSN:	0968-0896
Popis:	The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30eae9a8e1b6c198c1783bdf976bbb4 https://pubmed.ncbi.nlm.nih.gov/8770394 Zobrazit plný text záznamu Full Text from ScienceDirect