Overexpression of mineralocorticoid receptors partially prevents chronic stress-induced reductions in hippocampal memory and structural plasticity
| Autor: | Anjanette P. Harris, Marian Joëls, Harm J. Krugers, Brenna C. Fearey, Sofia Kanatsou, Paul J. Lucassen, Laura E. Kuil, Jonathan R. Seckl |
|---|---|
| Přispěvatelé: | Brain and Cognition, Structural and Functional Plasticity of the nervous system (SILS, FNWI), SILS (FNWI) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Neurogenesis Conditioning Classical Hippocampus lcsh:Medicine Mice Transgenic Hippocampal formation Biology Biochemistry Memory Neuroplasticity Animals Chronic stress Cognitive decline lcsh:Science Medicine(all) Multidisciplinary Neuronal Plasticity Behavior Animal Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Dentate gyrus lcsh:R Correction Long-term potentiation Fear Neurosecretory Systems Mice Inbred C57BL Receptors Mineralocorticoid nervous system lcsh:Q Neuroscience Stress Psychological Research Article Genetics and Molecular Biology(all) |
| Zdroj: | PLoS ONE [E], 10(11). Public Library of Science PLoS ONE, Vol 10, Iss 11, p e0142012 (2015) PLoS ONE, 10(11):e0142012. Public Library of Science PLoS ONE Kanatsou, S, Fearey, B C, Kuil, L E, Lucassen, P J, Harris, A P, Seckl, J R, Krugers, H & Joels, M 2015, ' Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity ', PLoS ONE, vol. 10, no. 11, pp. e0142012 . https://doi.org/10.1371/journal.pone.0142012 |
| ISSN: | 1932-6203 |
| Popis: | Exposure to chronic stress is a risk factor for cognitive decline and psychopathology in genetically predisposed individuals. Preliminary evidence in humans suggests that mineralocorticoid receptors (MRs) may confer resilience to these stress-related changes. We specifically tested this idea using a well-controlled mouse model for chronic stress in combination with transgenic MR overexpression in the forebrain. Exposure to unpredictable stressors for 21 days in adulthood reduced learning and memory formation in a low arousing hippocampus-dependent contextual learning task, but enhanced stressful contextual fear learning. We found support for a moderating effect of MR background on chronic stress only for contextual memory formation under low arousing conditions. In an attempt to understand potentially contributing factors, we studied structural plasticity. Chronic stress altered dendritic morphology in the hippocampal CA3 area and reduced the total number of doublecortin-positive immature neurons in the infrapyramidal blade of the dentate gyrus. The latter reduction was absent in MR overexpressing mice. We therefore provide partial support for the idea that overexpression of MRs may confer resilience to the effects of chronic stress on hippocampus-dependent function and structural plasticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|