Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation
| Autor: | Franziska Bruns, Sabine Wicker, Edith Klahold, Christian Seidl, Marissa Penna-Martinez, Klaus Badenhoop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry Parathyroid hormone Type 2 diabetes Biochemistry Calcitriol receptor DBP Cohort Studies chemistry.chemical_compound Endocrinology Vitamin D Vitamin D3 24-Hydroxylase Randomized Controlled Trials as Topic GC Aged 80 and over Vitamin D-Binding Protein General Medicine Middle Aged Treatment Outcome Cholestanetriol 26-Monooxygenase Female Metabolic Networks and Pathways Preliminary Data Adult medicine.medical_specialty Genotype Polymorphism Single Nucleotide CYP24A1 CYP27B1 Internal medicine Genetic predisposition medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Risk factor Cytochrome P450 Family 2 Genetic Association Studies VDR Aged 25-Hydroxyvitamin D3 1-alpha-Hydroxylase business.industry Endocrine Care Biochemistry (medical) medicine.disease Vitamin D Deficiency Pharmacogenomic Testing chemistry Diabetes Mellitus Type 2 Case-Control Studies Dietary Supplements CYP2R1 Receptors Calcitriol Cholecalciferol business |
| Zdroj: | Hormone and Metabolic Research |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Variants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D). This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 “G” (pc=0.031), rs1544410 “G” (pc=0.027) and CYP2R1 rs10741657 “A” (pc=0.016). Patients with genotypes CYP27B1 rs10877012 “CC” (pc=4x10-5), DBP rs7041 “GG” (pc=0.003), rs4588 “CC” (pc = 3x10-4), CYP24A1 rs2585426 “CG” (pc=0.006) and rs2248137 “CG” (pc=0.001) showed lower 25(OH)D3 and DBP rs4588 “CC” lower 1,25(OH)2D3 levels (pc=0.005). Whereas DBP rs4588 “CC” (pc=0.009), CYP27B1 rs10877012 “AC” (pc=0.059), VDR rs7975323 “AG” (pc=0.033) and rs1544410 “GG” (pc=0.013) are associated with higher 25(OH)D3 levels at 6 months’ follow-up. Significant PTH suppression was detected for CYP2R1 “AG“ (pc=0.002), DBP rs4588 “CC” (pcGenetic variants of the vitamin D system predispose to type 2 diabetes and regulate – partially - vitamin D metabolism, concentrations and the vitamin D status. Vitamin D insufficiency is a T2D risk factor. The response to cholecalciferol supplementation can be measured as 25(OH)D3 increment and PTH suppression. This process is regulated by genes of the vitamin D system conferring modest T2D risk. |
| Databáze: | OpenAIRE |
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