Influence of Energy Balance and Glycemic Index on Metabolic Endotoxemia in Healthy Men
| Autor: | Nicolle Breusing, Merit Lagerpusch, Manfred J. Mueller, Anna Janina Engstler, Anja Bosy-Westphal, Ina Bergheim |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Energy balance Medicine (miscellaneous) 030209 endocrinology & metabolism Hyperphagia Body weight Energy requirement Fasting insulin Body Mass Index Metabolic endotoxemia 03 medical and health sciences 0302 clinical medicine Insulin resistance Weight loss Internal medicine medicine Humans Caloric Restriction Nutrition and Dietetics Chemistry Body Weight medicine.disease Lipids Endotoxemia Diet Endotoxins 030104 developmental biology Glycemic index Endocrinology Glycemic Index Insulin Resistance medicine.symptom Energy Intake Energy Metabolism |
| Zdroj: | Journal of the American College of Nutrition. 36:72-79 |
| ISSN: | 1541-1087 0731-5724 |
| DOI: | 10.1080/07315724.2016.1156036 |
| Popis: | Overfeeding with a high-fat and/or high-carbohydrate (CHO) diet is known to increase plasma concentrations of endotoxin (lipopolysaccharide [LPS]) that may lead to metabolic disturbances like insulin resistance. The impact of CHO quality (i.e., the glycemic index [GI]) independent of fat intake on metabolic endotoxemia remains unclear. In the present study, the effects of changes in energy balance and GI on plasma endotoxin were studied.Fifteen healthy young men overconsumed diets containing 65% CHO and 20% fat for 1 week (OF; +50% of energy requirement) followed by 3 weeks of caloric restriction (CR; -50% of energy requirement) and were then randomized to 2 weeks hypercaloric refeeding (RF, +50% of energy requirement) with either a low- or high-GI (40 vs 74) diet.During OF, subjects gained 1.9 ± 0.7 kg body weight (+0.6 ± 0.8% fat mass) followed by a weight loss of 6.1 ± 0.8 kg (-2.0 ± 0.6% fat mass) and weight regain of 4.0 ± 0.6 kg (0.9 ± 0.8% fat mass). Fasting insulin and homeostasis model assessment-insulin resistance (HOMAA hypercaloric diet (OF and RF) increased plasma endotoxin irrespective of GI, whereas a negative energy balance did not reduce endotoxemia. Impaired insulin sensitivity with hypercaloric refeeding on a high-GI diet was not explained by metabolic endotoxemia. |
| Databáze: | OpenAIRE |
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