Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes
| Autor: | Liang Wu, Peng-Fei Zhou, Xiao-Juan Yu, Tong-Huan Li, Chun-Jian Qiu, Dan-Dan Liu |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
lcsh:RC648-665 Article Subject endocrine system diseases Receiver operating characteristic Adiponectin Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism nutritional and metabolic diseases Type 2 diabetes medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology female genital diseases and pregnancy complications Gestational diabetes Endocrinology PEDF Diabetes mellitus Internal medicine medicine Biomarker (medicine) PIGMENT EPITHELIUM-DERIVED FACTOR business Research Article |
| Zdroj: | International Journal of Endocrinology, Vol 2015 (2015) International Journal of Endocrinology |
| ISSN: | 1687-8345 1687-8337 |
| DOI: | 10.1155/2015/346938 |
| Popis: | Background. Pigment epithelium-derived factor (PEDF) is demonstrated to be elevated in diabetes patients. However, no reports have emerged in pregnant women with gestational diabetes mellitus (GDM). This study was undertaken to investigate serum PEDF levels in GDM women and to evaluate PEDF as a biomarker to predict diabetes postpartum.Methods. Serum PEDF concentration and clinical characteristics were detected in the pregnant women with GDM (n = 120) and without GDM (control group,n = 120).Results. PEDF levels were elevated in subjects with GDM versus controls. Univariate correlations showed that serum PEDF levels were positively correlated with fasting glucose and fasting insulin levels, respectively, and negatively correlated with adiponectin. Receiver operating characteristic (ROC) analysis demonstrated that the AUC of serum PEDF for diabetes mellitus in women postpartum was 0.893.Conclusion. Serum PEDF was elevated in pregnant women with GDM, which is probably an early detection marker for predicting development of GDM to diabetes mellitus. |
| Databáze: | OpenAIRE |
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