Vaginal delivery for fetuses at risk of alloimmune thrombocytopenia?
| Autor: | Dick Oepkes, Humphrey H.H. Kanhai, Esa van den Akker, Anneke Brand |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Pregnancy Risk Factors Epidemiology medicine Humans Caesarean section Prospective Studies Risk factor Gynecology Fetus Obstetrics Vaginal delivery business.industry Platelet Count Infant Newborn Pregnancy Outcome Obstetrics and Gynecology medicine.disease Delivery Obstetric Thrombocytopenia Cord blood Neonatal alloimmune thrombocytopenia Gestation Female business Intracranial Hemorrhages |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecology. 113(7) |
| ISSN: | 1470-0328 |
| Popis: | Objectives To evaluate the safety of vaginal delivery in pregnancies with fetal and neonatal alloimmune thrombocytopenia (FNAIT). Design Prospective data collection. Setting Leiden University Medical Centre, the national centre for management of severe red cell and platelet alloimmunisation. Population Thirty-two pregnancies with FNAIT, with a sibling with thrombocytopenia but without an intracranial haemorrhage (ICH). Methods The mode of delivery, platelet count in cord blood and neonatal outcome were analysed. All women received weekly intravenous immunoglobulin from 32 to 38 weeks of gestation. Head ultrasound scan was performed in all neonates. Main outcome measures Signs of ICH or other bleeding in the neonates. Results Twenty-three women delivered vaginally. Nine caesarean sections were performed, all for obstetric reasons. Median platelet count at birth was 142 × 109/l (range, 4–252 × 109/l), with severe thrombocytopenia ( |
| Databáze: | OpenAIRE |
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